DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas TNA's backbone is composed of repeating threose units linked by phosphodiester bonds. The threose molecule is easier to assemble than ribose making it a possible precursor to RNA.
DNA-TNA hybrid chains have been made in the laboratory using DNA polymerase.
TNA can specifically base pair with RNA and DNA; this capability and chemical simplicity suggests that TNA could have preceded RNA as genetic material.
* "Was simple TNA the first nucleic acid on Earth to carry a genetic code?", New Scientist
ORIGIN OF LIFE: A Simpler Nucleic Acid", Leslie Orgel
* Orgel, Leslie (November 2000). "A Simpler Nucleic Acid". Science 290 (5495): 1306–1307. doi:10.1126/science.290.5495.1306.
* Watt, Gregory (February 2005). "Modified nucleic acids on display". Nature Chemical Biology. doi:10.1038/nchembio005. http://www.nature.com/nchembio/journal/vaop/nprelaunch/full/nchembio005.html.
* Schoning, K;
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