Guillaume François Rouelle (1703–1770) was a French chemist and apothecary. In 1754 he introduced the concept of a base into chemistry, as a substance which reacts with an acid to give it solid form (as a salt).
He is known as l'Aîné (the elder) to distinguish him from his younger brother, Hilaire Rouelle, who was also a chemist and known as the discoverer of urea.
He started a public course in his laboratory in 1738 where he taught many students among whom were Denis Diderot, Antoine-Laurent de Lavoisier, Joseph Proust and Antoine-Augustin Parmentier.
He was elected a foreign member of the Royal Swedish Academy of Sciences in 1749.
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* Warolin, C. (1996). "Did Lavoisier benefit from the teachings of the apothecary Guillaume-François Rouelle?". Histoire des sciences médicales 30 (1): 30. PMID 11624829.
* Warolin, C. (1995). "Did Lavoisier benefit from the teachings of the apothecary Guillaume-François Rouelle?". Revue d'histoire de la pharmacie 42 (307): 361–367. PMID 11624913.