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Martin Chalfie (born January 15, 1947) is an American scientist. He is the William R. Kenan, Jr. Professor of Biological Sciences at Columbia University, where he is also chair of the department of biological sciences.[1] He shared the 2008 Nobel Prize in Chemistry along with Osamu Shimomura and Roger Y. Tsien "for the discovery and development of the green fluorescent protein, GFP".[2] He holds a Ph.D. in neurobiology from Harvard University.


Chalfie grew up in Chicago, Illinois.

He matriculated at Harvard University in 1965, intending to be a math major[3], but he switched to biochemistry because it combined his interests in chemistry, math, and biology.[3] He spent the summer after his junior year working in the laboratory of Klaus Weber at Harvard, but "It was so disheartening to completely fail that I decided I shouldn’t be in biology."[4] As a result, in his senior year, he completed his major and took courses in law, theater, and Russian literature. [3]

He also competed on the swim team at Harvard and was named captain in his senior year. At the time, swimming coach Bill Brooks said, "Marty will make an excellent captain because he has the admiration of the entire team."[5] As captain, he won the Harold S. Ulen trophy, awarded "to a senior on the Harvard team who best demonstrates those qualities of leadership, sportsmanship, and team cooperation as exemplified by Harold S. Ulen." [6] Following the announcement Nobel award, his freshman-year roommate observed of Chalfie, “He would always identify himself as a swimmer.”[4]

After graduating in 1969, he worked at a variety of temporary jobs, such as selling dresses for his parents' dress manufacturing business in Chicago [3] and teaching at Hamden Hall Country Day School in Hamden, Connecticut.[3] In the summer of 1971, his research at the laboratory of Jose Zadunaisky at Yale University resulted in his first publication. With revived confidence,[3] he returned to Harvard for graduate studies under Robert Perlman, and received his Ph.D. in 1977.

He conducted his postdoctoral research at the LMB with Sidney Brenner and John Sulston, and the three published a paper in 1985 on "The Neural Circuit for Touch Sensitivity in C. elegans".[7] Chalfie then left the LMB in 1982 to join the faculty of Columbia University in the department of biological sciences and continued to study C. elegans touch mutants.

He married Tulle Hazelrigg. She later joined him on the faculty of Columbia University.[3] She gave him permission to cite her unpublished research in his seminal Science paper "Green Fluorescent Protein as a Marker for Gene Expression"[8] on condition that he made coffee, cooked, and emptied the garbage nightly for a month[9]

Chalfie was elected to the National Academy of Sciences in 2004.

He slept through the phone call from the Nobel Prize Committee.[4][10] When he woke up, he knew the prize would have been announced already, so he said "Okay, who's the schnook that got the Prize this time?" And so he opened up his laptop, got to the Nobel Prize site and found out that he was the schnook![10]
Scientific work

Chalfie's lab uses the nematode C. elegans to investigate aspects of nerve cell development and function. The wealth of developmental, anatomical, genetic, and molecular information available for C. elegans provides a powerful and multifaceted approach to these studies.

He has published over 200 papers of which at least 16 have over 100 citations.[11]

He traces his work on Green fluorescent protein to a 1988 seminar from Paul Brehm about bioluminescent organisms: this led to some crucial experiments in 1992, detailed in his paper “Green fluorescent protein as a marker for gene expression”,[12] which is among the 20 most-cited papers in the field of Molecular Biology & Genetics.[13]

Martin Chalfie (Columbia University): Developing GFP as a Biological Marker


1. ^ The Nobel Prize in Chemistry 2008
2. ^ Website of the Nobel Prize committee.
3. ^ a b c d e f g Tinsley Davis in Proceedings of the National Academy of Sciences (2008-01-28). "Profile of Martin Chalfie". National Academy of Sciences. http://www.pnas.org/content/105/5/1393.full.
4. ^ a b c June Q. Wu (2008-10-09). "Harvard Alumni Win Nobel Prize". Harvard Crimson. http://www.thecrimson.com/article.aspx?ref=524525.
5. ^ "Chalfie is named tankers' captain". Harvard Crimson. 1968-03-21. http://www.thecrimson.com/article.aspx?ref=139729.
6. ^ Bennett H. Beach (1969-04-18). "Two Awards Presented To Diver Bill Murphy". Harvard Crimson. http://www.thecrimson.com/article.aspx?ref=494782.
7. ^ "The Neural Circuit for Touch Sensitivity in C. Elegans"
8. ^ Chalife et al. "Green Fluorescent Protein as a Marker for Gene Expression" Science 263:802-805, 1994
9. ^ Nobel Lecture slide 17
10. ^ a b Adam Smith. "Interview with Martin Chalfie". Nobel Foundation. http://nobelprize.org/nobel_prizes/chemistry/laureates/2008/chalfie-telephone.html.
11. ^ Google Scholar
12. ^ Chalfie, M.; et al. (1994). "Green fluorescent protein as a marker for gene expression". Science 263 (5148): 802–805. doi:10.1126/science.8303295.
13. ^ In-cites.com

Chemistry Encyclopedia

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