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Xiaoliang Sunney Xie (born 1962 in Beijing, China) is the Mallinckrodt Professor of Chemistry and Chemical Biology at Harvard University. Xie is considered a founding father of single-molecule enzymology. He has also made major contributions to biomedical imaging by developing CARS microscopy.

Xie received a B.S. in chemistry from Peking University, followed by his Ph.D. in 1990 from the University of California at San Diego. He conducted postdoctoral research at the University of Chicago and in 1992 joined Pacific Northwest National Laboratory, where he later became a Chief Scientist. In 1999, he became the first full professor at Harvard University from the People's Republic of China.

Among the first to conduct fluorescence studies of single molecules at room temperature in the early 1990s, his research group has contributed to the emergence of the field of single-molecule biophysical chemistry and its application to biology. His work focuses on single-molecule enzymology, protein conformational dynamics, and the study of gene expression and regulation in living cells. His group also pioneered CARS microscopy and stimulated Raman scattering microscopy, sensitive biomedical imaging techniques that allow 3D imaging of live cells and organisms based on vibrational spectroscopy.[1]

Honors and Awards

* 2009: Ernest Orlando Lawrence Award
* 2008: Fellow of the American Physical Society
* 2008: Berthold Leibinger Zukunftspreis for Applied Laser Technology [2]
* 2008: Fellow of the American Academy of Arts and Sciences
* 2007: Willis E. Lamb Award for Laser Sciences and Quantum Optics [3]
* 2006: Fellow of Biophysical Society
* 2006: Fellow of the American Association for the Advancement of Science
* 2004: National Institutes of Health Director's Pioneer Award[4]
* 2003: Raymond and Beverly Sackler Prize in the Physical Sciences
* 1996: Coblentz Award

Selected Literature

* C.W. Freudiger, W. Min, B.G. Saar, S.Lu, G.R. Holtom, C. He, J.C. Tsai, J.X. Kang, X.S. Xie: "Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy." Science 322, 1857 (2008).
* P.J. Choi, L. Cai, K. Frieda, X.S. Xie: "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell." Science 322, 422 (2008).
* J. Elf, G. Li, X.S. Xie: "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell." Science 316, 1191 (2007).
* J. Yu, J. Xiao, X. Ren, K. Lao, X.S. Xie: "Probing Gene Expression in Live Cells, One Protein Molecule at a Time." Science 311, 1600 (2006).
* L. Cai, N. Friedman, X.S. Xie: "Stochastic Protein Expression in Individual Cells at the Single Molecule Level." Nature 440, 358 (2006).
* B.P. English, W. Min, A.M. van Oijen, K. T. Lee, G. Luo, H. Sun, B.J. Cherayil, S.C. Kou, X.S. Xie: "Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited." Nat. Chem. Bio. 2, 87 (2006).
* H. Yang, G. Luo, P. Karnchanaphanurach, T.-M. Louie, I. Rech,S. Cova, L. Xun, X.S. Xie: "Protein Conformational Dynamics Probed by Single-molecule Electron Transfer." Science 302, 262 (2003).
* A. Zumbusch, G.R. Holtom, X.S. Xie: "Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering." Phys. Rev. Lett. 82, 4142 (1999).
* H.P. Lu, L. Xun, X.S. Xie: "Single-Molecule Enzymatic Dynamics." Science 282, 1877 (1998).
* X.S. Xie, R.C. Dunn: "Probing Single Molecule Dynamics." Science 265, 361 (1994).

References

1. ^ http://bioopticsworld.com/display_article/361473/131/none/none/Depar/Sunney-Xie
2. ^ [http://www.leibinger-stiftung.de/2.laureates_zukunftspreis-2008.html
3. ^ Biography of Xie from the Website of the Willis E. Lamb Award (displayed June 4, 2008)
4. ^ http://nihroadmap.nih.gov/pioneer/Profiles04/Xie.aspx


External links

* Homepage of the Xie Group at Harvard

List of Chemists

Chemistry Encyclopedia

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