Aristolochia

Life-forms

Classification System: APG IV

Superregnum: Eukaryota
Regnum: Plantae
Cladus: Angiosperms
Cladus: Magnoliids
Ordo: Piperales

Familia: Aristolochiaceae
Subfamilia: Aristolochioideae
Genus: Aristolochia
Species
a

A. acontophylla – A. acuminata – A. acutifolia – A. adalica – A. adiastola – A. albertiana – A. albida – A. albopilosa – A. alexandriana – A. altanii – A. amara – A. andina – A. anguicida – A. angustifolia – A. annamensis – A. apoloensis – A. arborea – A. arborescens – A. arcuata – A. arenicola – A. argentina – A. asclepiadifolia – A. asperifolia – A. assamica – A. assisii – A. atropurpurea – A. auricularia – A. australopithecurus – A. austrochinensis – A. austroszechuanica – A. austroyunnanensis
b

A. baenzigeri – A. baetica – A. bahiensis – A. balansae – A. bambusifolia – A. baracoensis – A. barbourii – A. baseri – A. batucensis – A. biakensis – A. bianorii – A. bicolor – A. bidoupensis – A. bilabiata – A. billardieri – A. bilobata – A. binhthuanensis – A. birostris – A. bodamae – A. boliviensis – A. bonettiana – A. boosii – A. bottae – A. bracteolata – A. bracteosa – A. brevifolia – A. brevilabris – A. brevipes – A. bridgesii – A. brunneomaculata – A. buchtienii – A. bukuti – A. bullata – A. buntingii – A. burchellii – A. burelae – A. burkartii
c

A. cabrerae – A. californica – A. cambodiana – A. cardiantha – A. carterae – A. castellanosii – A. cathcartii – A. caudata – A. caulialata – A. cauliflora – A. ceresensis – A. ceropegioides – A. chachapoyensis – A. chalmersii – A. chamissonis – A. championii – A. chilensis – A. chiquitensis – A. chlamydophylla – A. chrismuelleriana – A. chrysochlora – A. cilicica – A. clavidenia – A. clematitis – A. clementis – A. clusii – A. coadunata – A. cochinchinensis – A. colimensis – A. colombiana – A. colossifolia – A. compressicaulis – A. consimilis – A. constricta – A. contorta – A. conversiae – A. cordiflora – A. cordigera – A. cornuta – A. cortinata – A. coryi – A. crassinervia – A. cremersii – A. cretica – A. cucurbitifolia – A. cucurbitoides – A. curtisii – A. curviflora – A. cymbifera – A. cynanchifolia
d

A. dabieshanensis – A. daemoninoxia – A. dalyi – A. davilae – A. debilis – A. decandra – A. delavayi – A. deltantha – A. deltoidea – A. dictyophlebia – A. didyma – A. dielsiana – A. dilatata – A. dinghoui – A. disticha – A. durangensis
e

A. echinata – A. ehrenbergiana – A. ekmanii – A. embergeri – A. emiliae – A. engleriana – A. erecta – A. eriantha – A. esperanzae
f

A. fangchi – A. faucimaculata – A. faviogonzalezii – A. feddei – A. filipendulina – A. fimbriata – A. flava – A. flexuosa – A. floribunda – A. foetida – A. fontanesii – A. fordiana – A. forrestiana – A. fosteri – A. foveolata – A. fragrantissima – A. fujianensis – A. fulvicoma
g

A. gabonensis – A. gardneri – A. gaudichaudii – A. gehrtii – A. geniculata – A. gentilis – A. gibertii – A. gigantea – A. ginzbergeri – A. glaberrima – A. glandulosa – A. glaucifolia – A. glossa – A. goldieana – A. goliathiana – A. gongchengensis – A. gorgona – A. goudotii – A. gourigangaica – A. gracilifolia – A. gracilipedunculata – A. gracilis – A. grandiflora – A. grandis – A. griffithii – A. guadalajarana – A. guentheri – A. guianensis – A. guichardii – A. gurinderii
h

A. hainanensis – A. haitiensis – A. hansenii – A. harmandiana – A. helix – A. heppii – A. heterophylla – A. hians – A. hilariana – A. hirta – A. hispida – A. hockii – A. hoehneana – A. hohuanensis – A. holostylis – A. holtzei – A. howii – A. huanjiangensis – A. huberiana – A. huebneriana – A. humilis – A. hyperxantha – A. hypoglauca – A. hyrcana
i

A. iberica – A. impressinervis – A. impudica – A. incisa – A. incisiloba – A. indica – A. inflata – A. insolita – A. involuta – A. iquitensis – A. islandica
j

A. jackii – A. jianfenglingensis – A. jingiangensis
k

A. kaempferi – A. karwinskii – A. kechangensis – A. kepara – A. keratuma – A. killipiana – A. klossii – A. klugii – A. kongkandae – A. krausei – A. krisagathra – A. krukoffii – A. kunmingensis – A. kwangsiensis
l

A. labiata – A. lagesiana – A. laheyana – A. lanceolatolorata – A. lassa – A. lauterbachiana – A. lawrenceae – A. ledongensis – A. leonensis – A. leprieurii – A. leptosticta – A. leuconeura – A. leytensis – A. liangshanensis – A. limai – A. lindeniana – A. lindneri – A. linearifolia – A. lingua – A. lingulata – A. linnemannii – A. littoralis – A. liukiuensis – A. longgangensis – A. longiflora – A. longispathulata – A. longissima – A. longlinensis – A. lorenae – A. lozaniana – A. lutea – A. lutescens – A. luudamcui – A. luzmariana – A. lycica
m

A. macedonica – A. macgregorii – A. macrocarpa – A. macrophylla – A. macroura – A. malacophylla – A. malmeana – A. manantlanensis – A. manaosensis – A. mannii – A. manokwariensis – A. manshuriensis – A. maranonensis – A. marianensis – A. marioniana – A. mathewsii – A. maurorum – A. maxima – A. medicinalis – A. meionantha – A. melanocephala – A. melanoglossa – A. melastoma – A. melgueiroi – A. meridionaliana – A. meridionalis – A. merxmuelleri – A. micrantha – A. microphylla – A. microstoma – A. minutiflora – A. mishuyacensis – A. mollis – A. mollissima – A. momandul – A. montana – A. monticola – A. morae – A. mossii – A. moupinensis – A. mulunensis – A. mutabilis – A. mycteria
n

A. nahua – A. nakaoi – A. nana – A. nardiana – A. nauseifolia – A. navicularis – A. naviculilimba – A. neinhuisii – A. nelsonii – A. neolongifolia – A. nevesarmondiana – A. novoguineensis – A. nuichuaensis – A. nummulariifolia
o

A. oaxacana – A. obliqua – A. oblongata – A. occidentalis – A. odora – A. odoratissima – A. olivieri – A. ophioides – A. oranensis – A. orbicularis – A. ornithopterae – A. ornithorhyncha – A. ovalifolia – A. ovatifolia
p

A. pacayacensis – A. pacifica – A. paecilantha – A. pallida – A. palmeri – A. panamensis – A. pannosoides – A. papillaris – A. papillifolia – A. paracleta – A. paradisiana – A. paramaribensis – A. parvifolia – A. passiflorifolia – A. paucinervis – A. paulistana – A. peltata – A. peltatodeltoidea – A. peninsularis – A. peninsulensis – A. pentandra – A. perangustifolia – A. peruviana – A. petelotii – A. petenensis – A. pfeiferi – A. phetchaburiensis – A. philippinensis – A. phuphathanaphongiana – A. physodes – A. pichinchensis – A. pierrei – A. pilosa – A. pilosistyla – A. pistolochia – A. pithecurus – A. platanifolia – A. pohliana – A. poluninii – A. polymorpha – A. pontica – A. poomae – A. pothieri – A. praevenosa – A. preussii – A. pringlei – A. promissa – A. prostrata – A. pseudocaulialata – A. pseudotriangularis – A. pseudoutriformis – A. pubera – A. pubescens – A. pueblana – A. punctata – A. punjabensis – A. purhepecha – A. purpusii – A. putumayensis
q

A. quangbinhensis – A. quercetorum
r

A. raja – A. repanda – A. reticulata – A. rhizantha – A. ridicula – A. rigida – A. ringens – A. robertii – A. rostrata – A. rotunda – A. rugosa – A. ruiziana – A. rumicifolia – A. rumphii – A. rzedowskiana
s

A. saccata – A. salweenensis – A. samanensis – A. samarensis – A. savannoidea – A. schippii – A. schlechteri – A. schmidtiana – A. schottii – A. schreiteri – A. schultzeana – A. schulzii – A. schunkeana – A. scytophylla – A. secunda – A. sempervirens – A. sepicola – A. sepikensis – A. sericea – A. serpentaria – A. sessilifolia – A. setosa – A. shimadae – A. sicula – A. silvatica – A. sinaloae – A. singalangensis – A. sinoburmanica – A. smilacina – A. socorroensis – A. sparusifolia – A. stahelii – A. stenocarpa – A. stenosiphon – A. steupii – A. stevensii – A. steyermarkii – A. stomachoidis – A. stuckertii – A. styoglossa – A. subglobosa – A. surinamensis
t

A. tadungensis – A. taliscana – A. tamnifolia – A. tanzawana – A. tapilulensis – A. tentaculata – A. tequilana – A. teretiflora – A. theriaca – A. thibetica – A. thozetii – A. thwaitesii – A. tigrina – A. tithonusiana – A. tomentosa – A. tonduzii – A. tongbiguanensis – A. tonkinensis – A. translucida – A. transsecta – A. transtillifera – A. tresmariae – A. triactina – A. trianae – A. triangularis – A. tricaudata – A. trichostoma – A. trilobata – A. trulliformis – A. truncata – A. tuberosa – A. tubiflora – A. tuitensis – A. tyrrhena
u

A. urbaniana – A. urupaensis – A. utriformis
v

A. vallisicola – A. variifolia – A. veracruzana – A. versabilifolia – A. versicolor – A. viperina – A. vitiensis – A. vuquangensis
w

A. wankeana – A. wardiana – A. warmingii – A. watsonii – A. weberbaueri – A. weddellii – A. weixiensis – A. wendeliana – A. wenshanensis – A. werdermanniana – A. westlandii – A. whitei – A. williamsii – A. wrightii – A. wuana
x

A. xerophytica – A. xuanlienensis
y

A. yachangensis – A. yalaensis – A. yangii – A. yujungiana – A. yungasensis – A. yunnanensis
z

A. zebrina – A. zenkeri – A. zhongdianensis – A. zollingeriana

Nothospecies: A. × domingensis – A. × gueneri – A. × gypsicola

Unplaced: A. burro – A. campestris – A. coriacea – A. cubensis – A. elevata – A. fastidiosa – A. hyperborea – A. lawrenceae – A. longicaulis – A. marsupiiflora – A. metriosa – A. microphylla – A. paraensis – A. piperifolia – A. uhdeana – A. × compta
Source(s) of checklist:
PWO

Paleospecies: †A. triangularis – †A. macginitieana

---

A. acuminata - A. anguicida - v A. arcuata - A. argyroneura - A. baetica - - A. bianorii - A. bilabiata - A. bilobata - A. bracteolata - A. californica - A. cauliflora - A. championii - A. chilensis - - A. clematitis - A. contorta - A. coryi - - A. cymbifera - A. debilis - A. elegans - A. erecta - A. esperanzae - A. fangchi - A. fimbriata - A. fordiana - - A. gigantea - A. glandulosa - A. grandiflora - - A. indica - A. labiata - A - A. littoralis - A. longgangensis - A. macrophylla - A. manshuriensis - - A. maxima -A. mollissima - - A. obliqua - A. odoratissima - - A. paucinervis - A. paulistana - A. peltata - A. pentandra - tii - A. pistolochia - - A. reticulata - A. ridicula - A. ringens - A. rotunda - A. rugosa - A. rumphii - - A. sempervirens - A. sericea - A. serpentaria - - A. surinamensis - A. tomentosa - - A. trilobata - - A. watsonii - A. westlandii - A. wrightii

Name

Aristolochia L., Sp. Pl. 2: 960 (1753).

Lectotype species: Aristolochia rotunda L. (designated by N. L. Britton & A. Brown, Ill. Fl. N.U.S. ed. 2, 1: 645. 1913, supported by Green, Prop. Brit. Bot.: 186. 1929.)

Synonyms

Heterotypic
Ambuya Raf., Fl. Tellur. 4: 98, 1836. (Type: Ambuya labiosa (Edwards) Raf.)
Cardiolochia Raf. ex Rchb., Consp. regn. veg.: 85. 1828. nom. nud.
Dasyphonion Raf., First Cat. Bot. Card. Transylv. Univ. 13, 1824. (Type: Dasyphonion tomentosum (Sims) Raf.)
Dictyanthes Raf. in Loud., Gard. Mag. 8: 247. 1832. (Type: Dictyanthes labiosa (Edwards) Raf.)
Diglosselis Raf., Fl. Tellur. 4: 98. 1838 (Type: Diglosselis trinervis Raf. = Aristolochia bilabiata L.)
Duchartrella Kuntze
Eimomenia Meisn.
Einomeia Raf., Med. Fl. 1: 62. 1828. (Type: Einomeia bracteata Raf. = Aristolochia pentandra L.)
Einomeria Rchb.
Endodaca Schlecht.
Endodeca Raf., Med. Fl. 1: 62. 1828. (Type: Endodeca hastaia (Nutt.) Raf.)
Endotheca Raf., Fl. Tellur. 4: 98 (1838).
Enomeia Spach
Eudodeca Steud.
Euglypha Chodat & Hassl., Bull. Herb. Boissier, Ser. II, 6: 138 (1906). sometimes accepted.
Glossula Rchb., Handb. nat. Pfl.-Syst., 173 (1837).
Guaco Liebm., Forhandl. Skandin. Naturf. vol. 1844, 203. 1847. (Type: Guaco mexicana Liebm.)
Hexaplectris Raf., Fl. Tellur. 4: 97. 1838. (Type: Hexaplectris bicolor (L.) Raf.)
Hocquartia Dum., Comm. Bot. 30, 1822. (Type: Hocquartia macrophylla (Lam.) Dum.)
Holostylis Duch., Ann. Sci. Nat., Bot. sér. 4, 2: 33. (1854)
Howardia Klotzsch, Monatsb. Acad. Berlin 1859: 607, 1859, nom. illeg. non Wedd. (1854). (Type: Howardia ringens (Vahl) Klotzsch)
Isiphia Raf., Med. fl. 2: 232. 1830. (Type: Isiphia glabra Raf. = Aristolochia sipho L'Herit.)
Isotrema Raf., Amer. Monthly Mag. & Crit. Rev. 4(3): 195. 1819. (Type: Isotrema sipho (L’Hérit.) Raf.)
Niphus Raf. ex Steud.
Pistolochia Raf., Fl. Tellur. 4: 98. 1838, nom. illeg.
Plagistra Raf., Fl. Tellur. 4: 98. 1838. (Type: Plagistra cretica (Lam.) Raf.)
Psophiza Raf., Fl. Tellur. 4: 98. 1838. (Type: Psophiza undulata Raf. = Aristolochia serpentaria L.)
Pteriphis Raf., Fl. Tellur. 4: 99. 1838. (Type: Pteriphis tripteris (Raf.) Raf.)
Siphidia Rchb.
Siphisia Raf., Medic. Fl. 1: 62, 1828. (Type: Siphisia glabra Raf. = Aristolochia sipho L'Herit.)
Tropexa Raf., Fl. Tellur. 4: 98, 1838. (Type: Tropexa biloba (L.) Raf.)

Note: There are differing opinions regarding the circumscription of this genus (Zhu et al., 2019 cf. Govaerts et al., 2022). See Discussion page for further details, but the above is a view of Aristolochia s.l., WS has to stay conservative.
References
Primary references

Linnaeus, C. 1753. Species Plantarum. Tomus II: 960. Reference page.
Linnaeus, C. 1754. Genera Plantarum, ed. 5: 410. Reference page.

Additional references

Britton, N.L. & Brown, A. 1913. An illustrated flora of the northern United States, Canada and the British possessions: from Newfoundland to the parallel of the southern boundary of Virginia, and from the Atlantic Ocean westward to the 102d meridian. ed. 2. C. Scribner's sons, New York. Vol. 1: 645. Reference page.
Buchwalder, K., Samain, M.-S., Sankowsky, G., Neinhuis, C. & Wanke, S. 2014. Nomenclatural updates of Aristolochia subgenus Pararistolochia (Aristolochiaceae). Australian Systematic Botany 27(1): 48–55. DOI: 10.1071/SB13042 Paywall ResearchGate Open access Reference page.
Hitchcock, A.S. & Green, M.L. 1929. Standard species of Linnaean genera of Phanerogamae (1753–1754). pp. 111–195. In: Sprague, T.A. (ed.): International Botanical Congress. Cambridge (England), 1930. Nomenclature. Proposals by British Botanists. His Majesty's Stationery Office, London. Biblioteca Digital Reference page.
Pfeifer, H.W. 1966. Revision of the North and Central American Hexandrous Species of Aristolochia (Aristolochiaceae). Annals of the Missouri Botanical Garden 53(2): 115–196. JSTOR BHL Reference page.
Zhu, X-X, Li, X-Q, Liao, S., Cheng, D., Wang, Y., Wang, Z-H., Yang. J., Zuo, Y-J. & Ma, J-S. 2019. Reinstatement of Isotrema, a new generic delimitation of Aristolochia subgen. Siphisia (Aristolochiaceae). Phytotaxa 401(1): 001-023. DOI: 10.11646/phytotaxa.401.1.1 Paywall ResearchGate Reference page.

Links

Govaerts, R. et al. 2022. Aristolochia in Kew Science Plants of the World Online. The Board of Trustees of the Royal Botanic Gardens, Kew. Published online. Accessed: 2022 Jan. 2. Reference page.
Hassler, M. 2018. Aristolochia. World Plants: Synonymic Checklists of the Vascular Plants of the World In: Roskovh, Y., Abucay, L., Orrell, T., Nicolson, D., Bailly, N., Kirk, P., Bourgoin, T., DeWalt, R.E., Decock, W., De Wever, A., Nieukerken, E. van, Zarucchi, J. & Penev, L., eds. 2018. Species 2000 & ITIS Catalogue of Life. Published online. Accessed: 2018 Dec. 29. Reference page.
Aristolochia L. in The International Fossil Plant Names Index (IFPNI)
International Plant Names Index. 2016. Aristolochia. Published online. Accessed: July 7 2016. Reference page.
USDA, ARS, Germplasm Resources Information Network. Aristolochia in the Germplasm Resources Information Network (GRIN), U.S. Department of Agriculture Agricultural Research Service.
Farr, E.R. & Zijlstra, G. (eds.) 1996 onwards. Aristolochia in Index Nominum Genericorum (Plantarum). Accessed: 2018 Dec. 29.
Tropicos.org 2018. Aristolochia. Missouri Botanical Garden. Published online. Accessed: 29 Dec. 2018.

Vernacular names
العربية: زراوند
azərbaycanca: Zəravənd
башҡортса: Алма үләне
беларуская: Кірказон
català: Aristolòquia
čeština: podražec
dansk: Slangerod-slægten
Deutsch: Pfeifenblumen
Ελληνικά: Αριστολοχία
English: Birthwort
Esperanto: Aristolokio
eesti: Tobiväät
فارسی: زرآوند
suomi: Piippuköynnökset
français: Aristoloche
עברית: ספלול
hornjoserbsce: Kokornak
magyar: Farkasalma
Ido: Aristolokio
日本語: ウマノスズクサ属
ქართული: ძირმწარა
қазақша: Жиренше
한국어: 쥐방울덩굴속
kurdî: Kundiroşk
lietuvių: Kartuolė
македонски: Волчје јаболко
മലയാളം: ആടുതൊടാപ്പാല
polski: Kokornak
русский: Кирказон
slovenčina: vlkovec
svenska: Piprankesläktet
తెలుగు: అరిస్టోలోకియా
ไทย: สกุลไก่ฟ้า
Türkçe: Loğusa otu
中文: 马兜铃

Aristolochia (English: /əˌrɪstəˈloʊkiə/) is a large plant genus with over 500 species that is the type genus of the family Aristolochiaceae. Its members are commonly known as birthwort, pipevine or Dutchman's pipe and are widespread and occur in the most diverse climates. Some species, like A. utriformis and A. westlandii, are threatened with extinction.

Isotrema is usually included here, but might be a valid genus. If so, it contains those species with a three-lobed calyx.
Description
Calico flower (A. littoralis): habit

Aristolochia is a genus of evergreen and deciduous lianas (woody vines) and herbaceous perennials. The smooth stem is erect or somewhat twining. The simple leaves are alternate and cordate, membranous, growing on leaf stalks. There are no stipules.

The flowers grow in the leaf axils. They are inflated and globose at the base, continuing as a long perianth tube, ending in a tongue-shaped, brightly colored lobe. There is no corolla. The calyx is one to three whorled, and three to six toothed. The sepals are united (gamosepalous). There are six to 40 stamens in one whorl. They are united with the style, forming a gynostemium. The ovary is inferior and is four to six locular.

These flowers have a specialized pollination mechanism. The plants are aromatic and their strong scent[2] attracts insects. The inner part of the perianth tube is covered with hairs, acting as a fly-trap. These hairs then wither to release the fly, covered with pollen.

The fruit is dehiscent capsule with many endospermic seeds.

The common names Dutchman's pipe and pipevine (e.g. common pipevine, A. durior) are an allusion to old-fashioned meerschaum pipes at one time common in the Netherlands and northern Germany. Birthwort (e.g. European birthwort A. clematitis) refers to these species' flower shape, resembling a birth canal. Aristolochia was first described by the 4th c. BC Greek philosopher and botanist Theophrastus in his ‘’Inquiry of Plants’’ [IX.8.3], and the scientific name Aristolochia was developed from Ancient Greek aristos (άριστος) "best" + locheia (λοχεία), childbirth or childbed, relating to its known ancient use in childbirth.[3][4] The Roman orator Cicero records a different tradition, that the plant was named for the otherwise unknown individual with the common Greek name Aristolochos, who had learned from a dream that it was an antidote for snake bites.[5]
Aristolochic acid, the main toxin of pipevines
Selected species
Main article: List of Aristolochia species

Aristolochia acuminata Lam.
Aristolochia acuminata habitus drawing
Aristolochia arborea
Aristolochia arborea flowers
Aristolochia baetica
Aristolochia boosii
Aristolochia bracteolata Lam. – worm killer
Aristolochia californica Torr. – California pipevine, California Dutchman's pipe
Aristolochia cauliflora Ule

Aristolochia chilensis

Aristolochia chilensis Bridges ex Lindl. – Chilean fox's ears
Aristolochia clematitis L. – European birthwort
Aristolochia contorta
Aristolochia cucurbitifolia Hayata
Aristolochia cucurbitoides C.F.Liang

Aristolochia eriantha
Aristolochia gibertii
Aristolochia gigantea
Aristolochia pistolochia
Aristolochia maxima

Aristolochia delavayi Franch.
Aristolochia didyma – yawar panga
Aristolochia durior (= A. macrophylla) – common Dutchman's pipe, common pipevine
Aristolochia eriantha
Aristolochia esperanzae Kuntze
Aristolochia fimbriata – white-veined Dutchman's pipe
Aristolochia gibertii
Aristolochia gigantea Mart. – giant pelican flower, Brazilian Dutchman's pipe
Aristolochia gorgona
Aristolochia grandiflora Sw. – pelican flower
Aristolochia hainanensis Merr.
Aristolochia indica L.
Aristolochia labiata Willd. – mottled Dutchman's pipe, rooster flower
Aristolochia lindneri
Aristolochia lindneri

Aristolochia littoralis

Aristolochia littoralis D.Parodi – elegant Dutchman's pipe, calico flower
Aristolochia longa – long aristolochia, sarrasine
Aristolochia macrophylla Lam.
Aristolochia macrophylla
Aristolochia macroura

Aristolochia pontica
Aristolochia sempervirens

Aristolochia maxima Jacq. – Florida Dutchman's pipe
Aristolochia obliqua S.M.Hwang
Aristolochia paecilantha
Aristolochia pistolochia L.
Aristolochia pontica
Aristolochia quangbinhensis
Aristolochia ringens Vahl – gaping Dutchman's pipe
Aristolochia rotunda L. – smearwort, round birthwort, English mercury, mercury goosefoot, allgood, tola bona, fat hen – type species
Aristolochia scytophylla S.M.Hwang & D.L.Chen
Aristolochia sempervirens L.
Aristolochia serpentaria L. – Virginia snakeroot
Aristolochia sipho L'Hér.
Aristolochia stevensii Barringer
Aristolochia tagala – Indian birthwort
Aristolochia thwaitesii Hook
Aristolochia tomentosa Sims – woolly pipevine, woolly Dutchman's pipe
Aristolochia tricaudata
Aristolochia trilobata
Aristolochia tuberosa C.F.Liang & S.M.Hwang
Aristolochia utriformis S.M.Hwang
Aristolochia watsonii Woot. & Standl. – Watson's Dutchman's pipe
Aristolochia westlandii Hemsl.
Aristolochia yunnanensis Franch.[6][7]

Swallowtail butterflies

Many species of Aristolochia are eaten by the caterpillar larvae of swallowtail butterflies, thus making themselves unpalatable to most predators. Lepidoptera feeding on pipevines include:

Choreutidae

Millieria leaf miner

Papilionidae

False Apollo (Archon apollinus) – known from numerous pipevine species
Bhutanitis
Bhutan glory (B. lidderdalii) – known from A. griffithi, A. kaempferii, A. mandshuriensis and maybe others[8][9]
Chinese three-tailed swallowtail (B. thaidina) – known from A. moupinensis
Troidini
Great windmill (Atrophaneura dasarada) – only known from A. griffithi
Common batwing (Atrophaneura varuna) – only known from A. kaempferi
Troides plateni – only known from Indian birthwort (A. tagala)
Cairns birdwing (Ornithoptera euphorion)
Richmond birdwing (O. richmondia)
Paradise birdwing (O. paradisea)
Rajah Brooke's birdwing (Trogonoptera brookiana) – only known from A. foveolata
Magellan birdwing (T. magellanus) – known on A. cucurbitifolia, A. ovatifolia, A. zollingeriana and maybe others
Pipevine swallowtail (Battus philenor) – known on A. macrophylla, Virginia snakeroot (A. serpentaria) and others
Polydamas Swallowtail (Battus polydamas)
Parides genus of swallowtails, also called cattlehearts
Zerynthiini
Allancastria caucasica
Eastern Festoon (Allancastria cerisyi) – known from numerous pipevine species [10]
Southern Festoon (Zerynthia polyxena) – known from numerous pipevine species
Spanish Festoon (Zerynthia rumina) – known from numerous pipevine species

In Australia the invasive Aristolochia littoralis is fatal to the caterpillars of Ornithoptera euphorion and O. richmondia and threatens to displace their proper host, A. tagala.
Herbalism, toxicity and carcinogenicity

The species Aristolochia clematitis was highly regarded as a medicinal plant since the ancient Egyptians, Greeks and Romans, and on until the Early Modern era; it also plays a role in traditional Chinese medicine. Due to its resemblance to the uterus, the doctrine of signatures held that birthwort was useful in childbirth. A preparation was given to women upon delivery to expel the placenta, as noted by the herbalist Dioscurides in the 1st century AD. Despite its presence in ancient medicine, Aristolochia is known to contain the lethal toxin aristolochic acid.

The Bencao Gangmu, compiled by Li Shi-Zhen in the latter part of the sixteenth century, was based on the author's experience and on data obtained from earlier herbals; this Chinese herbal classic describes 1892 "drugs" (with 1110 drawings), including many species of Aristolochia.[11] For 400 years, the Bencao Gangmu remained the principal source of information in traditional Chinese medicine and the work was translated into numerous languages, reflecting its influence in countries other than China. In the mid-twentieth century, the Bencao Gangmu was replaced by modern Materia Medica, the most comprehensive source being Zhong Hua Ben Cao (Encyclopedia of Chinese Materia Medica), published in 1999.[12] The Encyclopedia lists 23 species of Aristolochia, though with little mention of toxicity. The Chinese government currently lists the following Aristolochia herbs: A. manshuriensis (stems), A. fangchi (root), A. debilis (root and fruit), and A. contorta (fruit), two of which (madouling and qingmuxiang) appear in the 2005 Pharmacopoeia of the People's Republic of China.

In traditional Chinese medicine Aristolochia species are used for certain forms of acute arthritis and edema.[13][14][15]

Despite the toxic properties of aristolochic acid, naturopaths claim that a decoction of birthwort stimulates the production and increases the activity of white blood cells,[16] or that pipevines contain a disinfectant which assists in wound healing.[17] Also, Aristolochia bracteolata is colloquially known as "worm killer" due to supposed antihelminthic activity.[18]

Aristolochia taxa have also been used as reptile repellents. A. serpentaria (Virginia snakeroot) is thus named because the root was used to treat snakebite, as "so offensive to these reptiles, that they not only avoid the places where it grows, but even flee from the traveler who carries a piece of it in his hand".[19] A. pfeiferi,[20] A. rugosa,[21] and A. trilobata[22] are also used in folk medicine to treat snakebites.
Ornamental Aristolochia ringens
Toxicity and carcinogenicity

In 1993, a series of end-stage renal disease cases was reported[14][23][24] from Belgium associated with a weight loss treatment, where Stephania tetrandra in a herbal preparation was suspected of being replaced with Aristolochia fangchi.[25][26] More than 105 patients were identified with nephropathy following the ingestion of this preparation from the same clinic from 1990 to 1992. Many required renal transplantation or dialysis.[27] Aristolochia is a component of some Chinese herbal medicines.[28]

Aristolochia has been shown to be both a potent carcinogen and kidney toxin. Herbal compounds containing Aristolochia are classified as a Group 1 carcinogen by the International Agency for Research on Cancer.[29] Epidemiological and laboratory studies have identified Aristolochia to be a dangerous kidney toxin; Aristolochia has been shown to be associated with more than 100 cases of kidney failure.[30] Furthermore, it appears as if contamination of grain with European birthwort (A. clematitis) is a cause of Balkan nephropathy, a severe renal disease occurring in parts of southeast Europe.[31] In 2001 the UK government banned the sale, supply and importation of any medicinal product consisting of or containing a plant of the genus Aristolochia.[32] Several other plant species that do not cause themselves kidney poisoning, but which were commonly substituted with Aristolochia in the remedies, were prohibited in the same order.[33]

Aristolochic acid was linked to aristolochic acid-associated urothelial cancer in a Taiwanese study in 2012.[34] In 2013, two studies reported that aristolochic acid is a strong carcinogen. Whole-genome and exome analysis of individuals with a known exposure to aristolochic acid revealed a higher rate of somatic mutation in DNA.[35][36] Metabolites of aristolochic acid enter the cell nucleus and form adducts on DNA. While adducts on the transcribed DNA strand within genes are detected and removed by transcription-coupled repair, the adducts on the non-transcribed strand remain and eventually cause DNA replication errors. These adducts have a preference for adenine bases, and cause A-to-T transversions. Furthermore, these metabolites appear to show a preference for CAG and TAG sequences.
Garden history

Due to their spectacular flowers, several species are used as ornamental plants, notably the hardy A. durior of eastern North America, which was one of John Bartram's many introductions to British gardens; in 1761 Bartram sent seeds he had collected in the Ohio River Valley to Peter Collinson in London, and Collinson gave them to the nurseryman James Gordon at Mile End to raise. The vine was soon adopted for creating for arbors "a canopy impenetrable to the rays of the sun, or moderate rain," as Dr John Sims noted in The Botanical Magazine, 1801.[37]
Rajah Brooke's birdwing: its caterpillars feed on Aristolochia foveolata
See also

Nepenthes aristolochioides, a carnivorous plant with pitchers resembling Aristolochia flowers
Opodeldoc

Footnotes

"Genus: Aristolochia L." Germplasm Resources Information Network. United States Department of Agriculture. 2009-01-30. Retrieved 2011-01-08.
"sometimes with a very disagreeable odour" remarks the Royal Horticultural Society, Dictionary of Gardening.
"Jepson Manual: Aristolochia". Ucjeps.berkeley.edu. Retrieved 2013-08-15.
"Missouri Botanical Garden". Mobot.org. Retrieved 2013-08-15.
Cicero, On Divination 1.10.16
"GRIN Species Records of Aristolochia". Germplasm Resources Information Network. United States Department of Agriculture. Retrieved 2011-01-08.
"Aristolochia". Integrated Taxonomic Information System. Retrieved 2011-01-08.
"Bhutan Glory Butterfly". Knowledge Base.
"Bhutan Glory (Bhutanitis lidderdalii)". Astronomy to Zoology. 2015.
Tolman, T., 1997. Butterflies of Britain & Europe. Harper Collins
Grollman, Arthur P.; Scarborough, John; Jelaković, Bojan (2009). Chapter 7 Aristolochic Acid Nephropathy. Advances in Molecular Toxicology. Vol. 3. pp. 211–227. doi:10.1016/S1872-0854(09)00007-1. ISBN 9780444533579.
Health Department and National Chinese Medicine Management Office (ed.). Zhong Hua Ben Cao, 3–460–509. Shanghai Science Technology Publication. 1999.
Bensky, D., et al. Chinese Herbal Medicine: Materia Medica, Third Edition. 2004. pp 1054-55.
Vanherweghem, J-L.; Tielemans, C.; Abramowicz, D.; Depierreux, M.; Vanhaelen-Fastre, R.; Vanhaelen, M.; Dratwa, M.; Richard, C.; Vandervelde, D.; Verbeelen, D.; Jadoul, M. (February 1993). "Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs". The Lancet. 341 (8842): 387–391. doi:10.1016/0140-6736(93)92984-2. PMID 8094166. S2CID 32428737.
Vanhaelen, Maurice; Vanhaelen-Fastre, Renée; But, Paul; Vanherweghem, Jean-Louis (January 1994). "Identification of aristolochic acid in Chinese herbs". The Lancet. 343 (8890): 174. doi:10.1016/s0140-6736(94)90964-4. PMID 7904018. S2CID 34836561.
Chevallier, Andrew (2016). Encyclopedia of Herbal Medicine. Penguin. p. 171. ISBN 9781465456755.
Wood, Michael (March 2004). "Dutchman's Pipe (Aristolochia californica)". Yerbabuena org.
Nandhini, D Udhaya; Rajasekar, M; Venmathi, T (February 2017). "A review on worm killer: Aristolochia bracteolata" (PDF). Journal of Pharmacognosy and Phytochemistry.
Freeman-Mitford, A. B. The Bamboo Garden (1896) quoted in Alice M. Coats, Garden Shrubs and Their Histories (1964) 1992, s.v. "Aristolochia".
Ventocilla, Jorge; Herrera, Heraclio; Núñez, Valerio (2010). Plants and Animals in the Life of the Kuna. University of Texas Press. ISBN 9780292786790.
Uphof, J. C. Th. (1959). Dictionary of Economic Plants. la Universidad de Michigan.
Giovannini, Peter; Howes, Melanie-Jayne R. (March 2017). "Medicinal plants used to treat snakebite in Central America: Review and assessment of scientific evidence". Journal of Ethnopharmacology. 199: 240–256. doi:10.1016/j.jep.2017.02.011. PMID 28179114.
Depierreux, Michel; Van Damme, Baudewijn; Vanden Houte, Kaat; Vanherweghem, Jean Louis (August 1994). "Pathologic Aspects of a Newly Described Nephropathy Related to the Prolonged Use of Chinese Herbs". American Journal of Kidney Diseases. 24 (2): 172–180. doi:10.1016/s0272-6386(12)80178-8. PMID 8048421.
Vanhaelen, Maurice; Vanhaelen-Fastre, Renée; But, Paul; Vanherweghem, Jean-Louis (January 1994). "Identification of aristolochic acid in Chinese herbs". The Lancet. 343 (8890): 174. doi:10.1016/s0140-6736(94)90964-4. PMID 7904018. S2CID 34836561.
The names han fang ji (漢防己, Chinese fang ji - S. tetrandra) and guan fang ji (廣防己, Broad fang ji - A. fanchi) had apparently been confused.
Stiborová, M.; Frei, E.; Breuer, A.; Bieler, C.A.; Schmeiser, H.H. (July 1999). "Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy". Experimental and Toxicologic Pathology. 51 (4–5): 421–427. Bibcode:1999EToxP..51..421S. doi:10.1016/S0940-2993(99)80033-5. PMID 10445409.
Vergano, D. Herbal 'remedy' may trigger widespread kidney failure. USA Today April 16, 2012.
Li, X; Yang, L; Yu, Y (2001). "An analysis of the clinical and pathological characteristics of Mu-tong (a Chinese herb) induced tubulointerstitial nephropathy". Zhonghua Nei Ke Za Zhi. 40 (10): 681–7. PMID 11769723.
ACS (2006)
Cosyns, J. P. (2003). "Aristolochic acid and 'Chinese herbs nephropathy': a review of the evidence to date". Drug Saf. 26 (1): 33–48. doi:10.2165/00002018-200326010-00004. PMID 12495362. S2CID 46073980.
Grollman, Arthur P.; Shibutani, Shinya; Moriya, Masaaki; Miller, Frederick; Wu, Lin; Moll, Ute; Suzuki, Naomi; Fernandes, Andrea; Rosenquist, Thomas; Medverec, Zvonimir; Jakovina, Krunoslav; Brdar, Branko; Slade, Neda; Turesky, Robert J.; Goodenough, Angela K.; Rieger, Robert; Vukelić, Mato; Jelaković, Bojan (17 July 2007). "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proceedings of the National Academy of Sciences of the United States of America. 104 (29): 12129–12134. Bibcode:2007PNAS..10412129G. doi:10.1073/pnas.0701248104. PMC 1913550. PMID 17620607.
Statutory Instruments 2001 No. 1841. The Medicines (Aristolochia and Mu Tong etc.) (Prohibition) Order 2001. http://www.legislation.gov.uk/uksi/2001/1841/made
"Illegal herbal remedies containing Aristolochia: vigilance needed". GOV.UK. Retrieved 2023-08-24.
Chen, Chung-Hsin; Dickman, Kathleen G.; Moriya, Masaaki; Zavadil, Jiri; Sidorenko, Viktoriya S.; Edwards, Karen L.; Gnatenko, Dmitri V.; Wu, Lin; Turesky, Robert J.; Wu, Xue-Ru; Pu, Yeong-Shiau; Grollman, Arthur P. (22 May 2012). "Aristolochic acid-associated urothelial cancer in Taiwan". Proceedings of the National Academy of Sciences of the United States of America. 109 (21): 8241–8246. doi:10.1073/pnas.1119920109. PMC 3361449. PMID 22493262.
Poon, Song Ling; Pang, See-Tong; McPherson, John R.; Yu, Willie; Huang, Kie Kyon; Guan, Peiyong; Weng, Wen-Hui; Siew, Ee Yan; Liu, Yujing; Heng, Hong Lee; Chong, Soo Ching; Gan, Anna; Tay, Su Ting; Lim, Weng Khong; Cutcutache, Ioana; Huang, Dachuan; Ler, Lian Dee; Nairismägi, Maarja-Liisa; Lee, Ming Hui; Chang, Ying-Hsu; Yu, Kai-Jie; Chan-on, Waraporn; Li, Bin-Kui; Yuan, Yun-Fei; Qian, Chao-Nan; Ng, Kwai-Fong; Wu, Ching-Fang; Hsu, Cheng-Lung; Bunte, Ralph M.; Stratton, Michael R.; Futreal, P. Andrew; Sung, Wing-Kin; Chuang, Cheng-Keng; Ong, Choon Kiat; Rozen, Steven G.; Tan, Patrick; Teh, Bin Tean (7 August 2013). "Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool". Science Translational Medicine. 5 (197): 197ra101. doi:10.1126/scitranslmed.3006086. PMID 23926199. S2CID 25923013.
Hoang, Margaret L.; Chen, Chung-Hsin; Sidorenko, Viktoriya S.; He, Jian; Dickman, Kathleen G.; Yun, Byeong Hwa; Moriya, Masaaki; Niknafs, Noushin; Douville, Christopher; Karchin, Rachel; Turesky, Robert J.; Pu, Yeong-Shiau; Vogelstein, Bert; Papadopoulos, Nickolas; Grollman, Arthur P.; Kinzler, Kenneth W.; Rosenquist, Thomas A. (7 August 2013). "Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing". Science Translational Medicine. 5 (197): 197ra102. doi:10.1126/scitranslmed.3006200. PMC 3973132. PMID 23926200.

Quoted in Coats (1964) 1992.

References

American Cancer Society (ACS (2006): Known and Probable Carcinogens (Including Industrial Processes, Occupational Exposures, Infectious Agents, Chemicals, and Radiation). Version of 02/03/2006. Retrieved 2007-NOV-12.
Depierreux, Michel; Van Damme, Baudewijn; Vanden Houte, Kaat; Vanherweghem, Jean Louis (August 1994). "Pathologic Aspects of a Newly Described Nephropathy Related to the Prolonged Use of Chinese Herbs". American Journal of Kidney Diseases. 24 (2): 172–180. doi:10.1016/s0272-6386(12)80178-8. PMID 8048421.
Grollman, Arthur P.; Shibutani, Shinya; Moriya, Masaaki; Miller, Frederick; Wu, Lin; Moll, Ute; Suzuki, Naomi; Fernandes, Andrea; Rosenquist, Thomas; Medverec, Zvonimir; Jakovina, Krunoslav; Brdar, Branko; Slade, Neda; Turesky, Robert J.; Goodenough, Angela K.; Rieger, Robert; Vukelić, Mato; Jelaković, Bojan (17 July 2007). "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proceedings of the National Academy of Sciences of the United States of America. 104 (29): 12129–12134. Bibcode:2007PNAS..10412129G. doi:10.1073/pnas.0701248104. PMC 1913550. PMID 17620607.
Heinrich, Michael; Chan, Jennifer; Wanke, Stefan; Neinhuis, Christoph; Simmonds, Monique S.J. (August 2009). "Local uses of Aristolochia species and content of aristolochic acid 1 and 2 – a global assessment based on bibliographic sources". Journal of Ethnopharmacology. 125 (1): 108–144. doi:10.1016/j.jep.2009.05.028. PMID 19505558.
Stiborová, M.; Frei, E.; Breuer, A.; Bieler, C.A.; Schmeiser, H.H. (July 1999). "Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy". Experimental and Toxicologic Pathology. 51 (4–5): 421–427. Bibcode:1999EToxP..51..421S. doi:10.1016/S0940-2993(99)80033-5. PMID 10445409.

Further reading
Mathew, Jessy Elizabeth; Kaitheri, Srinivasan Keloth; DinakaranVachala, Seekarajapuram; Jose, Magi (2011). "Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica". Iranian Journal of Basic Medical Sciences. 14 (5): 422–427. PMC 3586839. PMID 23493617.